Kurum Yazarı "Tümkaya, Levent" TF, Cerrahi Tıp Bilimleri Bölümü Koleksiyonu İçin Listeleme
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Adalimumab ameliorates abdominal aorta cross clamping which induced liver injury in rats
Cüre, Erkan; Cüre, Medine Cumhur; Tümkaya, Levent; Kalkan, Yıldıray; Aydın, İbrahim; Kırbaş, Aynur; Yılmaz, Arif; Yüce, Süleyman; Yücel, Ahmet Fikret (Hindawi Ltd, 2014)The aim of this study was to investigate the possible protective effects of adalimumab (ADA) on cell damage in rat liver tissue during ischemia/reperfusion (I/R) injury of infrarenal abdominal aorta. Thirty male Wistar-albino ... -
Agomelatine on cisplatin-induced nephrotoxicity via oxidative stress and apoptosis
Dil, Eyüp; Topçu, Atilla; Mercantepe, Tolga; Tümkaya, Levent; Akyıldız, Kerimali; Saral, Sinan; Yılmaz, Adnan (Springer, 2023)Drug-induced nephrotoxicity is the greatest deterrent to the use of cisplatin, which is a frequently used chemotherapeutic with proven efectiveness in cancer therapy. Agomelatine, which is used in the treatment of sleep ... -
Biochemical and histopathological effects on the rat testis after exposure to electromagnetic field during fetal period
Şehitoğlu, İbrahim; Tümkaya, Levent; Kalkan, Yıldıray; Bedir, Recep; Cüre, Medine Cumhur; Zorba, Orhan Ünal; Cüre, Erkan; Yüce, Süleyman (Iniestares, S.A., 2015)OBJECTIVES: Electromagnetic radiation (ER) emitted from cell phones may exert a detrimental influence on human health and may affect the man reproductive system. We aimed to study the biological and morphological effects ... -
Clinical and histologic evaluation of partial achilles tendon ınjury repair with amniotic membrane in rats
Background: Adhesions after tendinopathy in individuals who perform physical work and those physically active in middle age are a challenging problem for orthopedic surgeons. We evaluated the effects of human-derivated ... -
Comparison of effects of dexmedetomidine and amifostine against X-ray radiation-induced parotid damage
Şafak, Gökhan; Çeliker, Metin; Tümkaya, Levent; Mercantepe, Tolga; Rakıcı, Sema; Çınar, Seda; Yılmaz, Adnan; Terzi, Suat; Demir, Emine; Erdivanlı, Özlem Çelebi; Coşkun, Zerrin Özergin; Karakaş, Sibel; Birinci, Mehmet; Dursun, Engin (Springer, 2022)Radiotherapy can be employed as a therapeutic modality alone in the early stages of cancer and is used together with other treatments such as surgery and chemotherapy in more advanced stages. However, exposure to ionizing ... -
Comparison of linear versus macrocyclic gadolinium chelates in rat skeletal muscle
Balık, Mehmet Sabri; Çeliker, Fatma Beyazal; Tümkaya, Levent; Mercantepe, Tolga; Topçu, Atilla; Şahin, Rıfat; Balık, Gülşah (2022)OBJECTIVE: We investigated the effects on skeletal muscle of gadolinium based linear and macrocyclic radiocontrast agents applied at experimental intervals using histopathological methods. METHODS: Thirty-two male ... -
Cystic schwannoma of the right brachial plexus causing thoracic outlet syndrome
Sönmez, Osman Fikret; Tümkaya, Levent; Kanat, Ayhan; Demir, Zafer; Baş, Orhan (Ondokuz Mayıs University, 2012)A rare case of a schwannoma of the right brachial plexus presenting with a cystic lesion is presented here. A 36-year-old man was admitted to our department with numbness, pain and progressive, lingering paralysis in the ... -
Dexmedetomidine alleviates vacuolization and necrosis in tubular epithelial cells induced by aortic cross-clamping
Ergene, Şaban; Hemşinli, Doğuş; Karakişi, Sedat Ozan; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, Adnan (Verduci Publisher, 2023)OBJECTIVE: Acute kidney inju-ry (AKI) is one of the main causes of mortality in patients undergoing emergency surgery due to an abdominal aortic aneurysm. This study aimed to determine the potential nephroprotec-tive ... -
Dexmedetomidine attenuates pneumocyte apoptosis and inflammation induced by aortic ischemia-reperfusion injury
Hemşinli, Doğuş; Tümkaya, Levent; Ergene, Şaban; Karakişi, Sedat Ozan; Mercantepe, Tolga; Yılmaz, Adnan (Taylor & Francis Ltd., 2022)Objective Despite significant improvements in interventional vascular aneurysm repair procedures and intensive care patient management, there has been no significant decrease in mortality due to ruptured abdominal aortic ... -
The effect of combined hyperbaric oxygen and iloprost treatment on the prevention of spinal cord ischaemia-reperfusion injury: an experimental study (vol 44, e332, 2013) - [Correction]
İlhan, Gökhan; Aksun, Murat; Özpak, Berkan; Güneş, Tevfik; Bozok, Şahin; Durakoğlugil, Murtaza Emre; Tümkaya, Levent; Gürbüz, Ali (Oxford Univ Press Inc, 2014).... -
The effect of dexmedetomidine on liver injury secondary to lower extremity ischemia-reperfusion in a diabetic rat model
Kartal, Seyfi; Şen, Ahmet; Tümkaya, Levent; Erdivanlı, Başar; Mercantepe, Tolga; Yılmaz, Adnan (Taylor & Francis Ltd., 2021)Introduction: In this study, we aimed to evaluate the hepatic protective effects of dexmedetomidine in the lower extremity ischemia-reperfusion model in diabetic rats biochemically and histopathologically. Methods: Rats ... -
Effect of infliximab on acute hepatic ischemia/reperfusion injury in rats
Yücel, Ahmet Fikret; Pergel, Ahmet; Aydın, İbrahim; Alaçam, Hasan; Karabıçak, İlhan; Kesicioğlu, Tuğrul; Tümkaya, Levent; Kalkan, Yıldıray; Arslan, Zakir; Şehitoğlu, İbrahim; Şahin, Dursun Ali (E-Century Publishing Corp, 2015)This study aimed to investigate the hepatoprotective and antioxidant effects of infliximab (IFX) against liver ischemia/reperfusion (I/R) injury in rats. A total of 30 male Wistar albino rats were divided into three groups: ... -
Effect of infliximab on renal injury due to methotrexate in rat
Kırbaş, Aynur; Cüre, Medine Cumhur; Kalkan, Yıldıray; Cüre, Erkan; Tümkaya, Levent; Şahin, Osman Zikrullah; Yüce, Süleyman; Kızılkaya, Bayram; Pergel, Ahmet (Iranian Soc Nephrolgy, 2015)Introduction. Methotrexate, an antagonist of folic acid used in the treatment of many cancers and inflammatory diseases, is associated with side effects that limit its usage. Infliximab has been reported to have a protective ... -
The effect of prenatal exposure to 1800 MHz electromagnetic field on calcineurin and bone development in rats
Erkut, Adem; Tümkaya, Levent; Balık, Mehmet Sabri; Kalkan, Yıldıray; Güvercin, Yılmaz; Yılmaz, Adnan; Yüce, Süleyman; Cüre, Erkan; Şehitoğlu, İbrahim (Acta Cirurgica Brasileira, 2016)PURPOSE: To investigated the effects of exposure to an 1800 MHz electromagnetic field (EMF) on bone development during the prenatal period in rats. METHODS: Pregnant rats in the experimental group were exposed to radiation ... -
The effect of rocuronium, sugammadex, and their combination on cardiac muscle and diaphragmatic skeletal muscle cells
Kalkan, Yıldıray; Bostan, Habib; Tümkaya, Levent; Tomak, Yakup; Bostan, Mehmet; Yılmaz, Adnan; Türüt, Hasan; Temiz, Ahmet; Yalçın, Alper; Turan, Alparslan (Springer Link, 2012)Purpose: Rocuronium has been associated with muscle weakness when administered in prolonged infusions. The effect of sugammadex and rocuronium together on muscle is unknown. In this study, we examined the effects of ... -
Effect of sugammadex on rocuronium induced changes in pancreatic mast cells
Kalkan, Yıldıray; Tümkaya, Levent; Bostan, Habib; Tomak, Yakup; Altuner, Durdu; Yılmaz, Adnan; Erdivanlı, Başar; Bedir, Recep; Yalçın, Alper; Turan, Alparslan (Sage Publications Inc, 2015)Mast cells play a vital role in hypersensitivity reactions. Rocuronium is known to cause mast cell mobilization, hypersensitivity, and pancreatitis. the aim of this study was to investigate the effects of sugammadex on ... -
Effects of 900 MHz electromagnetic field on prenatal locomotor development in rats
Balık, Mehmet Sabri; Tümkaya, Levent; Şehitoğlu, İbrahim; Kalkan, Yıldıray; Yılmaz, Adnan; Balık, Gülşah; Erkut, Adem; Güvercin, Yılmaz; Mercantepe, Tolga (E-Century Publishing Corp, 2019)Introduction: the present study investigated the effects of 900 MHz electromagnetic field (EMF) on locomotor system development in pregnant rats. Materials and methods: Following impregnation, the rats were divided into a ... -
Effects of chronic exposure to electromagnetic waves on the auditory system
Özgür, Abdulkadir; Tümkaya, Levent; Terzi, Suat; Kalkan, Yıldıray; Erdivanlı, Özlem Çelebi; Dursun, Engin (Taylor & Francis Ltd, 2015)Conclusion: the results support that chronic electromagnetic field exposure may cause damage by leading to neuronal degeneration of the auditory system. Objectives: Numerous researches have been done about the risks of ... -
The effects of curcumin on wound healing in a rat model of nasal mucosal trauma
Emiroğlu, Gökhan; Coşkun, Zerrin Özergin; Kalkan, Yıldıray; Erdivanlı, Özlem Çelebi; Tümkaya, Levent; Terzi, Suat; Özgür, Abdulkadir; Demirci, Münir; Dursun, Engin (Hindawi Ltd, 2017)We explored the effects of topical curcumin on the healing of nasal mucosal wounds. A total of 32 Sprague-Dawley Albino rats were randomized in equal numbers into four groups, and unilateral nasal wounds were created using ...