Güncel Gönderiler: TF, Temel Tıp Bilimleri Bölümü Koleksiyonu
Toplam kayıt 687, listelenen: 1-20
-
The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndrome
(BMC, 2025)BackgroundPlacental syndrome, mainly composed of preeclampsia and fetal growth restriction, has an impact on the health of mother and baby dyads. While impaired placentation is central to their pathophysiology, the underlying ... -
Role of coagulation factors in hepatocellular carcinoma: a literature review
(MDPI, 2025)Hepatocyte carcinoma (HCC) is a globally prevalent neoplasm with profound effects on morbidity and mortality rates. This review summarizes the complex interactions between coagulation abnormalities and the pathophysiological ... -
Investigation of ITGB3 heterogeneity to overcome trastuzumab resistance in HER2-positive breast cancer
(MDPI, 2025)HER2-positive breast cancer has an aggressive tumour progression among breast cancers characterized by the overexpression of HER2. Trastuzumab is an FDA-approved drug and has significantly improved outcomes for patients; ... -
Identification and characterization of a novel rat MAVS variant modulating NFκB signaling
(MDPI, 2025)The innate immune response serves as the primary defense against viral infections, with the recognition of viral nucleic acids by pattern recognition receptors (PRRs) initiating antiviral responses. Mitochondrial ... -
Is punica granatum efficient against sepsis? A comparative study of amifostine versus pomegranate
(MDPI, 2025)Sepsis is a clinical condition causing tissue damage as a result of infection and an exaggerated immune response. Sepsis causes 11 million deaths annually, a third of which are associated with acute lung injury (ALI). Rapid ... -
Investigation of the effects of fosfomycin in kidney damage caused by CLP-induced sepsis
(MDPI, 2025)Sepsis, a life-threatening condition characterized by dysregulated host responses to infection, often leads to multi-organ dysfunction, including kidney injury. Kidney damage in sepsis can have severe consequences and is ... -
Investigation of the preventive effect of methylsulfonylmethane on alveolar bone loss and oxidative stress in a rat model of periodontitis
(BMC, 2025)Background To investigate the preventive efficacy of methylsulfonylmethane (MSM) on alveolar bone destruction in rats with periodontitis. Methods Twenty-four male Sprague-Dawley rats were randomly divided into three groups: ... -
Effects of 5 G mobile phone network electromagnetic field exposure on testicular endoplasmic reticulum stress and the protective role of coenzyme Q10
(Elsevier, 2025)Aim. Nowadays, the electromagnetic field (EMF) has become an issue of electromagnetic pollution . This study aimed to determine the effect of 5 G Fr1 frequency band EMF waves on endoplasmic reticulum (ER) stress in testicular ... -
Notch and hedgehog signalling axis drive senescence in HER2-positive breast cancer resistant to trastuzumab
(Istanbul University Press, 2024)Objective: Cellular senescence halts the proliferation of damaged or preneoplastic cells, playing a vital role in cancer control. In HER2-positive breast cancer, resistance to trastuzumab, a HER2-targeted monoclonal antibody, ... -
CDC20 and CCNB1 overexpression as prognostic markers in bladder cancer
(MDPI, 2025)Background: Bladder cancer (BC) is one of the ten most common cancers worldwide, with a high recurrence rate and significant variation in clinical outcomes based on tumor grade and stage. This study aimed to investigate ... -
Does radioactive iodine treatment affect thyroid size and tracheal diameter?
(MDPI, 2025)Background/Objectives: There exist three principal treatment modalities employed in the management of hyperthyroidism attributable to excessive hormone secretion by the thyroid gland: antithyroid pharmacotherapy, surgical ... -
Mastectomy, HER2 receptor positivity, NPI, late stage and luminal B-type tumor as poor prognostic factors in geriatric patients with breast cancer
(MDPI, 2025)Background/Objectives: This study aims to explore the risk factors associated with poor survival outcomes in geriatric female patients with breast cancer. Methods: This study utilized data from the METABRIC database to ... -
Type 2 diabetes risk among master swimmers: a case–control study
(Springer Nature, 2025)Purpose: This study seeks to evaluate the impact of regular physical activity, particularly swimming, on type 2 diabetes (T2DM) risk scores, as measured by the Finnish Diabetes Risk Score (FINDRISC), among competitive ... -
Hi-labspermmorpho: a novel expert-labeled dataset with extensive abnormality classes for deep learning-based sperm morphology analysis
(IEEE, 2024)Sperm morphology is crucial in semen analysis for diagnosing male infertility. To reduce limitations in visual assessment, such as variability in biological conditions and the biologist's experience, developing computer-based ... -
White tea reduces dyslipidemia, inflammation, and oxidative stress in the aortic arch in a model of atherosclerosis induced by atherogenic diet in apoe knockout mice
(MDPI, 2024)Objective: In this study, we aimed to evaluate the potential effects of white tea (WT) in the atherosclerosis process characterized by oxidative stress, inflammation, and dyslipidemia. Methods: In our study, apolipoprotein ... -
Dexmedetomidine improves learning functions in male rats modeling cognitive impairment by modulating the BDNF/TrkB/CREB signaling pathway
(MDPI, 2024)Dexmedetomidine (DEX) is a selective alpha-2 adrenergic receptor agonist with sedative and anxiolytic properties. Increasing evidence reports that DEX has a neuroprotective effect. In this study, we investigated the potential ... -
Effect of white tea on leptin and asprosin levels in rats feeding a high-fat diet
(MDPI, 2024)Background: Currently, obesity affects over 600 million individuals and is responsible for numerous severe health conditions, particularly diabetes and metabolic syndrome. The objective of our study was to examine the ... -
Rates of PCR positivity of pleural drainage fluid in COVID-19 patients: is it expected?
(MDPI, 2024)Background: Tube thoracostomy, utilized through conventional methodologies in the context of pleural disorders such as pleural effusion and pneumothorax, constitutes one of the primary therapeutic interventions. Nonetheless, ... -
Evaluation of serum galectin-3 concentration as a potential biomarker in exudative-type age-related macular degeneration
(Nature Research, 2024)To investigate the effect of serum galectin-3 on naive neovascular AMD and its use as a serum marker by revealing the variation in this molecule between patient and control groups. Fifty-six naive neovascular AMD patients ...
